Tuning Insect Odorant Receptors

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Tuning Insect Odorant Receptors

Citation: Wicher D (2018) Tuning Insect Odorant Receptors. Front. Cell. Neurosci. 12:94. doi: 10.3389/fncel.2018.00094 Among the insect olfactory receptors the odorant receptors (ORs) evolved in parallel to the onset of insect flight. A special property of this receptor type is the capability to adjust sensitivity of odor detection according to previous odor contacts. This article presents a cu...

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Insect Odorant Receptors: Channeling Scent

Odorant detection in insects involves heterodimers between an odorant receptor (OR) and a conserved seven-transmembrane protein called Or83b, but the exact mechanism of OR signal transduction is unclear. Two recent studies in Nature (Sato et al., 2008; Wicher et al., 2008) now reveal that these OR-Or83b heterodimers form odorant-gated ion channels, revealing a surprising new mode of olfactory t...

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The narrowing olfactory landscape of insect odorant receptors

The molecular basis of odorant detection and its corollary, the task of the odorant receptor, are fundamental to understanding olfactory coding and sensory ecology. Based on their molecular receptive range, olfactory receptors have been classified as pheromone and non-pheromone receptors, which are respectively activated by a single pheromone component (“specialist”) or by multiple odorant liga...

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Mammalian odorant receptor tuning breadth persists across distinct odorant panels

The molecular receptive range (MRR) of a mammalian odorant receptor (OR) is the set of odorant structures that activate the OR, while the distribution of these odorant structures across odor space is the tuning breadth of the OR. Variation in tuning breadth is thought to be an important property of ORs, with the MRRs of these receptors varying from narrowly to broadly tuned. However, defining t...

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ژورنال

عنوان ژورنال: Frontiers in Cellular Neuroscience

سال: 2018

ISSN: 1662-5102

DOI: 10.3389/fncel.2018.00094